SELECTED PUBLICATIONS:

SELECTED PUBLICATIONS:

Publications

SELECTED PUBLICATIONS:

​*Equal Contribution

# Corresponding Author

  • Jomaa*, A, Gamerdinger*, M, Hsieh*, H, Wallisch, A, Chandrasekaran, V, Ulsoy, Z, Scaiola, A, Hegde, RS, Shan#, S, Ban#, N, Deuerling#, E. 2022. Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Science. Feb 25;375(6583):839-844. doi: 10.1126/science.abl6459.

  • Jomaa, A#, Eitzinger, S, Zhu, Z, Chandrasekar, S, Kobayashi, K, Shan#, S, Ban#, N. 2021. Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle. Cell Reports. Jul 13;36(2):109350. doi: 10.1016/j.celrep.2021.109350.

  • Lee*, JH, Jomaa*#, A, Chung, S, Hwang Fu YH, Qian, R, Sun, X, Chandrasekar S, Hsieh, HH, Bi, X, Mattei, S, Boehringer, D, Weiss, S, Ban#, N, Shan#, S. 2021. Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. Science Advances. May 21;7(21):eabg0942. doi: 10.1126/sciadv.abg0942.

  • Wang*, S, Jomaa*, A, Jaskolowski, M, Yang, CI, Ban, N, Shan, S. 2019. Molecular mechanism of co-translational membrane protein recognition and targeting by SecA. Nat Struct Mol Biol. Oct;26(10):919-929.

  • Kobayashi*, K, Jomaa*, A, Lee, JH, Chandrasekar, S, Boehringer, D, Shan, So, Ban, N. 2018. Structure of a pre-handover mammalian ribosomal SRP•SRP receptor targeting complex. Science. 2018 Apr 20;360(6386):323-327 

  • Jomaa, A, Hwang Fu, YH, Boehringer, D, Leibundgut, M, Shan, So, Ban, N. 2017. Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome. Nat Comm. May 19;8:15470.

  • Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. 2016. Structures of the E. coli translating ribosome with the SRP and its receptor and with the translocon. Nat Comm. Jan 25;7:10471.

IMG_20211111_140926_resized_20211127_101122135.jpg

CHRONOLOGICAL ORDER

  • During post-doctoral training:​

*Equal Contribution

# Corresponding Author

(21) Jomaa*, A, Gamerdinger*, M, Hsieh*, H, Wallisch, A, Chandrasekaran, V, Ulsoy, Z, Scaiola, A, Hegde, RS, Shan#, S, Ban#, N, Deuerling#, E. 2022. Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Science. Feb 25;375(6583):839-844. doi: 10.1126/science.abl6459.

(20) Kavalchuk*, M, Jomaa*#, A, Müller, AU, Weber-Ban#, E. 2022 Structural basis of prokaryotic ubiquitin-like protein engagement and translocation by the mycobacterial Mpa-proteasome complex. Nat. Comms. Jan 12;13(1):276. doi: 10.1038/s41467-021-27787-3.

(19)  Jomaa#, A, Eitzinger, S, Zhu, Z, Chandrasekar, S, Kobayashi, K, Shan#, S, Ban#, N. 2021. Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle. Cell Reports. Jul 13;36(2):109350. doi: 10.1016/j.celrep.2021.109350.

 

(18) Lee*, JH, Jomaa*#, A, Chung, S, Hwang Fu YH, Qian, R, Sun, X, Chandrasekar S, Hsieh, HH, Bi, X, Mattei, S, Boehringer, D, Weiss, S, Ban#, N, Shan#, S. 2021. Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. Science Advances. May 21;7(21):eabg0942. doi: 10.1126/sciadv.abg0942.

 

(17) Schubert*, K, Karousis*, ED, Jomaa, A, Scaiola, A, Echeverria, B, Gurzeler, LA, Leibundgut, M, Thiel, V, Mühlemann, O, Ban, N. 2020. SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translation. Nat Struct Mol Biol. Sep 9. doi: 10.1038/s41594-020-0511-8.

 

(16) Wang*, S, Jomaa*, A, Jaskolowski, M, Yang, CI, Ban, N, Shan, S. 2019. Molecular mechanism of co-translational membrane protein recognition and targeting by SecA. Nat Struct Mol Biol. Oct;26(10):919-929. (Recommended in Faculty of 1000 Prime)

 

(15) Gamerdinger*, M, Kobayashi*, K, Wallisch, A,  Kreft, SG, Sailer, C, Schlömer, R, Sachs, N, Jomaa, A, Stengel, Ban, N, Deuerling, E. 2019. Early scanning of nascent polypeptides inside the ribosomal tunnel by NAC. Mol Cell. Sep 5;75(5):996-1006.

 

(14) Ziemski M, Jomaa, A, Mayer, D, Rutz, S, Giese, C, Verpintsev, D, Weber-Ban, E. 2018 Cdc48-like protein of actinobacteria (Cpa) is a novel proteasome interactor in mycobacteria and related actinobacteria. Elife. 2018 May 29;7. pii: e34055

 

(13) Kobayashi*, K, Jomaa*, A, Lee, JH, Chandrasekar, S, Boehringer, D, Shan, So, Ban, N. 2018. Structure of a pre-handover mammalian ribosomal SRP•SRP receptor targeting complex. Science. 2018 Apr 20;360(6386):323-327 (Recommended in Faculty of 1000 Prime)

 

(12)  Jomaa, A, Hwang Fu, YH, Boehringer, D, Leibundgut, M, Shan, So, Ban, N. 2017. Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome. Nat Comm. May 19;8:15470.

 

(11)  Jomaa, A, Boehringer, D, Leibundgut, M, Ban, N. 2016. Structures of the E. coli translating ribosome with the SRP and its receptor and with the translocon. Nat Comm. Jan 25;7:10471. (Recommended in Faculty of 1000 Prime)

 

 

  • During graduate studies:

 

(10)  Jomaa *, A, Jain* N, Davis* JH, Williamson, JR, Britton, RA, Ortega J. 2014. Functional domains of the 50S subunit mature late in the assembly process. Nucleic Acids Res. Mar;42(5):3419-35.     

 

(9)  Chen, C, Jomaa, A, Ortega, J, and Alani, EE. 2014. Pch2 is a hexameric ring ATPase that remodels the chromosome axis protein Hop1. Proc Natl Acad Sci U S A. Jan 7;111(1):E44-53.

 

(8) Leong, V, Kent, M, Jomaa, A, Ortega J. 2013. Escherichia coli rimM and yjeQ null strains accumulate immature 30S subunits of similar structure and protein complement. RNA. Jun;19(6):789-802.

 

(7) Jomaa, A, Stewart G, Mears, JA, Kireeva, I, Brown, ED, Ortega J. 2011. Cryoelectron microscopy structure of the 30S subunit in complex with the YjeQ biogenesis factor. RNA. Nov;17(11):2026-38. (Featured on the journal’s cover page)

 

(6) Capstick,DS, Jomaa, A, Hanke, C, Ortega, J, and Elliot MA 2011. Dual amyloid

domains promote differential functioning of the chaplin proteins during Streptomyces aerial morphogenesis. Proc Natl Acad Sci U S A. Jun 14;108(24):9821-6.

 

(5) Jomaa, A, Stewart, G, Martín-Benito, J, Zielke, R., Campbell, TL, Maddock JR,

Brown, E.D., J. Ortega. 2011. Understanding Ribosome Assembly: the Structure of

In vivo Assembled Immature 30S Subunits Revealed by Cryo-electron Microscopy. RNA. Apr;17(4):697-709.

 

 

  • During undergraduate studies:

 

(4) Ortega, J, Iwanczyk, J, Jomaa, A. 2009. Escherichia coli DegP: a structure driven functional model. J Bacteriol. Aug;191:4705-13. (Mini-review)

 

(3) Jomaa, A, Iwanczyk, J, Tran, J, Ortega, J, 2009. Characterization of the

autocleavage process of the Escherichia coli HtrA protein: implications for its

physiological role. J Bacteriol. Mar; 191:1924-32. (Featured on the journal’s cover page)

 

(2) Iwanczyk, J, Damjanovic, D, Kooistra, J., Leong, V., Jomaa, A, Ghirlando, R.,

Ortega, J. 2007. Role of the PDZ domains in Escherichia coli DegP Protein. J. Bacteriol. Apr; 189:3176-3186.

 

(1) Jomaa, A, Damjanovic, D, Leong, V, Ghirlando, R, Iwanczyk, J, Ortega, J. 2007.

The inner cavity of Escherichia coli DegP protein is not essential for molecular

chaperone and proteolytic activity. J. Bacteriol. Feb; 189:706-716. (Featured on the journal’s cover page).